Diabetes can cause peripheral neuropathy. With this condition there is dulled sensitivity of the nerves. Someone with this condition may not notice a sore on his or her foot for days. Nerve damage from diabetes is a major cause of diabetic ulcer. It can cause foot deformities (Charcot Foot) and gait changes that result in callus build up. It also causes loss of hair, sweat and oil gland function. This leads to dry scaly skin that cracks and breaks easily. All of these things can lead to ulceration and skin breakdown.
Diabetics are also prone to Peripheral Vascular Disease which is a condition where blood vessels become partially occluded by fatty deposits. This reduces the blood flow to the extremities and therefore reduces oxygen to the extremities.
Poor glucose control in Diabetics is also a contributing factor to diabetic ulcers. High blood sugar or hyperglycemia affects the body’s ability to fight infection when there is an open wound.